Ny. Shpigel et al., THE ANTIINFLAMMATORY DRUGS PHENYLBUTAZONE AND DIPYRONE IN THE TREATMENT OF FIELD CASES OF BOVINE MASTITIS, Journal of veterinary medicine. Series A, 43(6), 1996, pp. 331-336
The efficacy of phenylbutazone vs. dipyrone for the treatment of acute
clinical mastitis were compared in a clinical trial. All cows were tr
eated with 20g sulfadiazine and 4g trimethoprim i.m. upon diagnosis an
d half dosage once daily thereafter. In addition, the NSAIDs treated c
ows received once daily either 4g phenylbutazone or 20g dipyrone i.m.
for the duration of the antimicrobial therapy. In all treatment groups
the major causative organisms were coliforms. Recovery rates for the
controls, the phenylbutazone and dipyrone treatment groups were 81.8%,
89.4% and 86.6%, respectively Recovery was evaluated by the logistic
regression analysis, the odds ratios (OR) and their 95% confidence int
erval (CI) of treatment success for phenylbutazone and dipyrone treatm
ents relative to the control treatment were calculated. Odds ratio of
recovery was high for phenylbutazone (OR=2.42; CI=0.98-5.96; P=0.054)
as well as for dipyrone (OR=1.71; CI=0.98-3.00; P=0.060), demonstratin
g a strong trend towards improved recovery in NSAID groups. The odds o
f treatment failure for the phenylbutazone group relative to the dipyr
one group was 0.71 with 95% CI of 0.28-1.78. Clearly no significant di
fference could be demonstrated between phenylbutazone and dipyrone in
this field trial.