A. Weil et al., THE MTP40 GENE IS NOT PRESENT IN ALL STRAINS OF MYCOBACTERIUM-TUBERCULOSIS, Journal of clinical microbiology, 34(9), 1996, pp. 2309-2311
A multiplex PCR-based assay that targets IS6110 and the mtp40 gene was
evaluated for the rapid differentiation of Mycobacterium bovis and M.
tuberculosis, two of the causative agents of tuberculosis. The IS6110
target is present in both species, whereas the mtp40 gene was thought
to be specific for M. tuberculosis (P. Del Portillo, L. A. Murillo, a
nd M. E. Patarroyo, J. Clin. Microbiol. 29:2163-2168, 1991). However,
the mtp-40 gene is not present in all Ill. tuberculosis strains and; h
ence, is not useful for differentiating M. tuberculosis and M. bovis.