THE STUDY OF ERYTHROCYTES MEMBRANE, ATPASE ACTIVITIES, HEMORHEOLOGICAL CHANGES AND THEIR CORRELATION IN STROKE PATIENTS

Erythrocyte membrane lipids, ATPase activities, blood cell parameters and hemorheological changes were measured in 51 patients with acute ce rebral infarction, 12 patients with arteriosclerosis and 51 normal con trols. A decrease in erythrocyte deformability, ATPase activities and an increase in CHO/PL ratio and viscosity at high shear rate were obse rved in stroke patients in which a significant difference was found co mpared with that of the control group, Multivariate regression analysi s indicated that membrane lipids, ATPase activities, CHO/PL ratio visc osity at high shear rate had linear correlation with erythrocyte defor mability. The coefficient of multiple correlation was 0.8937. These fi ndings suggested that the erythrocyte membrane lipid composition and A TPase activities change significantly in stroke patients. These may be the cause of hemorheological disturbance. These changes existed befor e the occurrence of the stroke. So it is important to treat the circul ation disorder in arteriosclerosis patients to prevent the cerebral in farction. The adoption of treatment with drugs for improving microcirc ulation and ion transport may be of benefit in the recovery from a str oke. We concluded from our study that CHO/PL could be a feature of art eriosclerosis or strokes, and ATPase activities may serve as an early indication of the patient's state.