INTESTINAL-TYPE SINONASAL ADENOCARCINOMA - A SPORADIC CASE

A sporadic case of the intestinal-type sinonasal adenocarcinoma is des cribed. The patient was a comparatively young 33-year-old woman employ ed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenoc arcinoma with areas of more solid mucinous elements in the deeper part s of the neoplasm. The neoplasm had invaded the nasal septum and reach ed the left orbit invading the left ethmoidal sinus. The glands were l ined by columnar cells with elongated spindle-shaped nuclei and the ce lls expressed cytokeratin, carcinoembryonic antigen (CEA), Chromograni n A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no hist ory of wood dust inhalation and her exposure to chemicals is of some i nterest but had probably little or no role in the causation of this ne oplasm.