SUPEROVULATION AND INTRAUTERINE INSEMINATION VS SUPEROVULATION ALONE IN THE TREATMENT OF UNEXPLAINED INFERTILITY - A RANDOMIZED STUDY

OBJECTIVE: To assess whether intrauterine insemination (IUI) improves the fertility rates in women with unexplained infertility. STUDY DESIG N: We recruited 68 women with unexplained infertility and allocated th em randomly to treatment with three to five cycles of superovulation p lus IUI (36 patients) or superovulation alone (32 patients). Superovul ation was obtained with clomiphene citrate, human menopausal gonadotro pins and human chorionic gonadotropins. RESULTS: The cycle fecundity r ate ws 10% in patients who underwent superovulation alone and 19% in t hose treated with superovulation plus IUI (P < .05). CONCLUSIONS: Our results demonstrate that superovulation plus IUI is more effective tha n superovulation alone in the treatment of unexplained infertility.