Purpose: Submacular surgery for choroidal neovascularization (CNV) is
under investigation in the treatment of age-related macular degenerati
on (AMD) and the presumed ocular histoplasmosis syndrome. Four case st
udies are presented to demonstrate scanning laser ophthalmoscope (SLO)
testing in the pre- and postsurgical evaluation of visual function in
patients with subfoveal CNV secondary to AMD, presumed ocular histopl
asmosis syndrome, and submacular hemorrhage secondary to AMD. Methods:
Patients underwent a visual assessment pre- and 6 months postoperativ
ely, consisting of low vision visual acuity measurement, SLO macular p
erimetry of dense and relative scotomas, and analysis of the preferred
retinal locus for fixation (PRL) location and ability. Results: Visua
l acuity, dense and relative scotoma size and location, and PRL locati
on were compared; and relationships between anatomic and functional ch
anges were observed. Decreases in scotoma size and improvement in PRL
location and ability usually corresponded with improved visual acuity,
Preoperative scotoma and PRL location guided retinotomy site selectio
n. Conclusion: Scanning laser ophthalmoscope macular perimetry and PRL
testing may be useful adjuncts in the visual assessment of submacular
surgery and may advance understanding of the effects of submacular su
rgery on visual function, In addition, this testing may be used to pla
n location of surgical interventions for macular diseases.