TANDEM RADICAL REACTIONS OF ISONITRILES WITH 2-PYRIDONYL AND OTHER ARYL RADICALS - SCOPE AND LIMITATIONS, AND A FIRST GENERATION SYNTHESIS OF (+ -)-CAMPTOTHECIN/

Authors
CURRAN DP LIU H JOSIEN H KO SB
Citation
Dp. Curran et al., TANDEM RADICAL REACTIONS OF ISONITRILES WITH 2-PYRIDONYL AND OTHER ARYL RADICALS - SCOPE AND LIMITATIONS, AND A FIRST GENERATION SYNTHESIS OF (+ -)-CAMPTOTHECIN/, Tetrahedron, 52(35), 1996, pp. 11385-11404
Citations number
68
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
35
Year of publication
1996
Pages
11385 - 11404
Database
ISI
SICI code
0040-4020(1996)52:35<11385:TRROIW>2.0.ZU;2-P
Abstract
Photolysis of N-propargyl-6-halo-2-pyridones and related aromatic hali des in the presence of aryl isonitriles provides tetra- and pentacycli c products in a single step by a sequence of radical addition to the i sonitrile followed by two cyclizations. The scope and limitations of t he process are described along with a first generation synthesis of ra cemic camptothecin. Copyright (C) 1996 Elsevier Science Ltd