A NEW ROUTE TO GAMMA-ARYLIDENEBUTYROLACTONES VIA A TANDEM CARBOPALLADATION-HETEROCYCLIZATION SEQUENCE - A FORMAL SYNTHESIS OF U-68,215

Authors
CAVICCHIOLI M DECORTIAT S BOUYSSI D GORE J BALME G
Citation
M. Cavicchioli et al., A NEW ROUTE TO GAMMA-ARYLIDENEBUTYROLACTONES VIA A TANDEM CARBOPALLADATION-HETEROCYCLIZATION SEQUENCE - A FORMAL SYNTHESIS OF U-68,215, Tetrahedron, 52(35), 1996, pp. 11463-11478
Citations number
45
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
35
Year of publication
1996
Pages
11463 - 11478
Database
ISI
SICI code
0040-4020(1996)52:35<11463:ANRTGV>2.0.ZU;2-G
Abstract
Benzo-annulated enol lactones are obtained in good yields from pentyno ic acids 3- or 5-substituted with an iodo-aryl moiety by palladium-cat alyzed cyclization of their potassium carboxylates. Using this approac h, an efficient new route to U-68,215 is described. Copyright (C) 1996 Elsevier Science Ltd