MODERATE EXERCISE TRAINING AND LOW-ENERGY DIETS ARE ASSOCIATED WITH SMALL CHANGES IN INDEXES OF PLATELET-AGGREGATION AND BLOOD-COAGULATION IN OVERWEIGHT WOMEN

Because starvation or exhaustive exercise can significantly modify ind ices of platelet aggregation and blood coagulation, we investigated wh ether exercise training and energy restriction for weight-loss diets c ould also affect these indices. Ten healthy overweight women participa ted in an exercise program that gave an energy deficit of 15% for 98 d ays. Five women also ate 50% less food, giving them an overall energy deficit of 65%. Their diet contained > 100% of the recommended dietary allowance of all nutrients except energy. There were significant diff erences with time on the study (possibly caused by exercise training) for red blood cell, white blood cell, and platelet counts as well as a ctivated partial thromboplastin times (APTT) and platelet aggregation induced by collagen. Prothrombin time (PT) showed significant differen ces between groups, presumably caused by differences in energy intake. However, the changes caused by moderate exercise training and energy restriction diets are mild and probably have little physiological sign ificance.