EFFECT OF FLUVOXAMINE ON 5-HYDROXYTRYPTAMINE UPTAKE, PAROXETINE BINDING-SITES AND KETANSERIN BINDING-SITES IN THE JAPANESE MONKEY BRAIN ANDPLATELETS, IN-VIVO AND IN-VITRO

We investigated the in vitro effects of fluvoxamine on H-3-paroxetine binding and H-3-monoamine uptake in monkey cerebral cortex in comparis on with those of other antidepressants. Fluvoxamine selectively inhibi ted H-3-5-hydroxytryptamine (5-HT) uptake and H-3-paroxetine binding. However, it did not alter H-3-norepinephrine or H-3-dopamine uptake. I n addition, we examined the effects of chronic treatment with fluvoxam ine (5 mg/kg per day, p.o.) on 5-HT uptake sites that bind H-3-paroxet ine and 5-HT2 receptors that bind H-3-ketanserin, in monkey brains and platelets. Chronic treatment with fluvoxamine affected neither the pa roxetine binding sites nor the kentanserin binding sites of the brains and platelets. These results suggest that long-term treatment with fl uvoxamine does not affect either the 5-HT uptake sites or 5-HT2-recept ors of 5-HT neurons in monkey brain in spite of its strong inhibitory effect on 5-HT uptake in vitro.