Using Monte Carlo simulation, we investigate algorithms to identify an
d correct for detector Compton scatter in hypothetical PET modules wit
h 3x3x30 mm EGO crystals coupled to individual photosensors. Rather th
an assume a particular design, we study three classes of detectors: (1
) with energy resolution limited by counting statistics, (2) with ener
gy resolution limited by electronic noise, and (3) with depth of inter
action (DOI) measurement capability. For the first two classes, select
ing the channel with the highest signal as the crystal of interaction
yields a 22-25% misidentification fraction (MIF) for all reasonable no
ise fwhm to signal (N/S) ratios (i.e. <0.5 at 511 keV). Algorithms tha
t attempt to correctly position events that undergo forward Compton sc
atter using only energy information can reduce the MIF to 12%, and can
be easily realized with counting statistics limited detectors but can
only be achieved with very low noise values for noise limited detecto
rs. When using position of interaction to identify forward scatter, a
MTF of 12% can be obtained if the detector has good energy and positio
n resolution.