The solution q of the imaging equation Mq=FGq=p (F is the projector an
d G is a generalized backprojector) is determined using least squares,
thus various basis functions can be used as an expansion for the reco
nstructed image. In this paper a generalized natural pixel basis is ch
osen to allow flexibility in formulating the vector space for the solu
tion q. The singular value decomposition (SVD) method is used to solve
for q, and the final image is obtained by backprojecting q: p = Gq, a
nd sampling p at a discrete array of points. Truncated parallel and no
n-truncated fan beam projection measurements were used to demonstrate
that the solution q to Mq=FGq=p can be defined wherein, for example, i
f F is a fan beam projection operator, G can be a parallel backproject
ion operator defined based upon natural pixels. It is demonstrated tha
t different backprojection geometries can give almost equivalent recon
structions of non-truncated projections. For truncated projections the
estimation of q that covers the entire projection of the object is ef
fective in reducing ring artifacts; however, using more projection bin
s is much more effective in preserving the resolution than is increasi
ng the projection bin width. Also, a generalized natural pixel basis b
etter models the geometric response of a collimator used in SPECT, the
refore reconstructions of fan beam projections using generalized natur
al pixels are shown to have better resolution than those that use the
filtered backprojection algorithm.