The current study was performed to determine whether the Mammotome, a
new breast biopsy instrument, is better at harvesting breast tissue pe
rcutaneously than an automated Tru-Cut (ATC) device. A total of 345 st
ereotactic breast biopsies were performed with the Mammotome. The Mamm
otome specimens were clinically evaluated on a five-point specimen sca
le that reflected the quality and quantity of the specimens and the ra
pidity of collection. In selected cases, specimen weights from both te
chniques were measured. In addition, by examining the lesion site post
-biopsy, biopsies were categorized as incisional or excisional. Specim
ens obtained with the Mammotome were two times heavier than when obtai
ned with the Biopty(R) gun (34.3 mg vs. 17.2 mg, P less than or equal
to 0.0002). When aggregate Mammotome specimen weights were regressed a
gainst number of specimens submitted, average weight per specimen was
31.9 mg (P less than or equal to 0.0001). When compared with the ATC d
evice on the specimen scale, the Mammotome specimens were rated ''Aver
age'' in 2.1 percent, ''Good'' in 13 percent, and ''Very Good'' in 84.
9 percent. Also, 51.9 percent of the biopsies with the Mammotome were
judged to be incisional; 48.1 percent, excisional. Three minor complic
ations were encountered. The Mammotome more quickly harvests more brea
st tissue compared with ATC technology.