A CLINICAL-EVALUATION OF DEMINERALIZED FREEZE-DRIED BONE ALLOGRAFT INCOMBINATION WITH TETRACYCLINE IN THE TREATMENT OF PERIODONTAL OSSEOUSDEFECTS

Citation
Lb. Masters et al., A CLINICAL-EVALUATION OF DEMINERALIZED FREEZE-DRIED BONE ALLOGRAFT INCOMBINATION WITH TETRACYCLINE IN THE TREATMENT OF PERIODONTAL OSSEOUSDEFECTS, Journal of periodontology, 67(8), 1996, pp. 770-781
Citations number
40
Categorie Soggetti
Dentistry,Oral Surgery & Medicine
Journal title
ISSN journal
00223492
Volume
67
Issue
8
Year of publication
1996
Pages
770 - 781
Database
ISI
SICI code
0022-3492(1996)67:8<770:ACODFB>2.0.ZU;2-1
Abstract
THE PURPOSE WAS TO EVALUATE the use of demineralized freeze-dried bone allograft reconstituted with 50 mg/ml tetracycline hydrochloride in t he treatment of intrabony periodontal defects. Fifteen systemically he althy patients (12 females, 3 males; aged 35 to 61) with moderate-adva nced periodontitis were treated. Patients had 3 osseous defects with p robing depths (PD) > 5 mm after initial therapy. Each site in each sub ject was randomly assigned to one of the following groups: 1) deminera lized freeze-dried bone allograft reconstituted with 50 mg/ml tetracyc line (DFDBA + TCN); 2) demineralized freeze-dried bone allograft alone (DFDBA); or 3) debridement only (D). Clinical measurements were taken the day of surgery, 6 months, and 1 year. Standardized radiographs we re taken at baseline and 1 year and were evaluated by computer assiste d densitometric image analysis (CADIA). Clinical measurements included gingival recession, PD, clinical attachment level, and mobility. Osse ous defect measurements were taken at baseline and at the 1 year reent ry, No adverse healing responses occurred. The results showed that ail patients had a statistically significant improvement in probing depth and attachment Level at 1 year, Osseous measurements showed bone fill of 2.27 mm (51.6%) for the DFDBA + TCN group, 2.20 mm (52.4%) for the DFDBA group, and 1.27 mm (32.8%) for the D group. Defect resolution w as 77.3%; for the DFDBA + TCN group, 77.9% for the DFDBA group, and 63 .8% for the D group, The mean CADIA values were 5.01 fur the DFDBA + T CN group, 6.79 for the DFDBA group and 2.78 for tile D group. The CADI A values did not correlate with the clinical parameters. Although the grafted groups showed greater bone fill and defect resolution, there w as no statistically significant difference in any of the clinical para meters between the treatment groups. This study suggests that there is no significant benefit from reconstituting the allograft with 50 mg/m l of tetracycline hydrochloride.