METABOLISM OF 3-BETA-(2-HYDROXYETHOXY)CHO LEST-5-ENE AT THE INTRAVENOUS ADMINISTRATION TO RATS

The intravenous injection of 3 beta-(2-hydroxy-2-[H-3]ethoxy)cholest-5 -ene into rats with the cannulated common bile duct resulted in the pr imary accumulation of radioactivity in liver (24%) and spleen (12%) ti ssues, bile (7%), and blood serum (15%) after 3 hours. The distributio n of 3 beta-(2-hydroxy-2-[H-3]ethoxy)cholest-5-ene throughout various tissues was close to that of [C-14]cholesterol being administrated und er the same conditions. The analysis of radioactive products from bloo d serum showed that 40-60% of 3 beta-(2-hydroxy-2-[H-3]ethoxy)cholest- 5-ene was converted to the acyl derivative under experimental conditio ns.