OVULATION INDUCTION IN CLOMIPHENE-RESISTANT ANOVULATORY WOMEN WITH NORMAL DEHYDROEPIANDROSTERONE-SULFATE LEVELS - BENEFICIAL-EFFECTS OF THEADDITION OF DEXAMETHASONE DURING THE FOLLICULAR PHASE
Ea. Trott et al., OVULATION INDUCTION IN CLOMIPHENE-RESISTANT ANOVULATORY WOMEN WITH NORMAL DEHYDROEPIANDROSTERONE-SULFATE LEVELS - BENEFICIAL-EFFECTS OF THEADDITION OF DEXAMETHASONE DURING THE FOLLICULAR PHASE, Fertility and sterility, 66(3), 1996, pp. 484-486
Objective: To evaluate the effect on ovulation of a 10-day course of d
examethasone (DEX) initiated concurrently with a 5-day course of clomi
phene citrate (CC) in CC-resistant patients with normal DHEAS levels.
Design: Retrospective review. Settings: Patients from the clinical pra
ctice of the authors at the Medical College of Georgia, Augusta, Georg
ia. Patients: Thirteen oligomenorrheic women with normal DHEAS levels
who failed to ovulate on a graduated regimen of CC up to a dose of 150
mg for 5 days. Interventions: Ten-day course of DEX initiated concurr
ently with a 5-day course of CC; ovulation and pregnancy outcomes reco
rded. Main Outcome Measure: Pregnancy. Results: Eleven of 13 women bad
evidence of ovulation. Five clinical pregnancies were achieved. Concl
usion: These initial data support improvements in follicular developme
nt with an overlapping follicular phase regimen of CC and DEX in patie
nts with normal DHEAS levels and a previous poor response.