EFFECT OF STOBADINE ON GASTRIC-MUCOSAL INJURY AFTER ISCHAEMIA REPERFUSION/

Authors
MOJZIS J POMFY M KOHUT A BENES L NICAK A MIROSSAY L
Citation
J. Mojzis et al., EFFECT OF STOBADINE ON GASTRIC-MUCOSAL INJURY AFTER ISCHAEMIA REPERFUSION/, Physiologia bohemoslovaca, 45(5), 1996, pp. 399-403
Citations number
18
Journal title
Physiologia bohemoslovaca → ACNP
ISSN journal
03699463
Volume
45
Issue
5
Year of publication
1996
Pages
399 - 403
Database
ISI
SICI code
0369-9463(1996)45:5<399:EOSOGI>2.0.ZU;2-6
Abstract
The ability of stobadine to prevent gastric mucosal injury was tested in rat gastric ischaemia induced by 30 min clamping of the coeliac art ery with subsequent 30 min reperfusion. Serious injury of gastric muco sa (macroscopic and microscopic) and the increase of microvascular per meability was found after ischaemia/reperfusion in rats without stobad ine. After oral pretreatment with stobadine (5 mg.kg(-1), 30 min befor e surgery), the development of gastric mucosal lesions and changes of vascular permeability were significantly decreased.