Ab. Skaare et al., MOUTHRINSES CONTAINING TRICLOSAN REDUCE THE INCIDENCE OF RECURRENT APHTHOUS ULCERS (RAU), Journal of clinical periodontology, 23(8), 1996, pp. 778-781
Triclosan, an antibacterial agent introduced in toothpastes and mouthr
inses, has recently been shown to have anti-inflammatory and analgesic
properties. The aim of the present double-blind cross-over study was
to examine the effect of triclosan on the incidence of reccurent aphth
ous ulceration (RAU) when administered in mouthrinses. The study inclu
ded 30 patients with a history of multiple recurrent aphthous ulcers.
Three different triclosan-containing mouthrinses, differing only in th
eir solubilizing agents were used and compared with a control rinse. T
he number of new ulcers, ulcer-free days and the severity of pain were
recorded. The results showed that the patients experienced a signific
ant decrease in the number of oral ulcers during the experimental peri
od when the mouthrinses contained triclosan. It may thus be concluded
that triclosan has the potential to reduce the number of aphthous ulce
rs presumably due to its antiinflammatory properties.