FREQUENT DELETION OF CHROMOSOME 1P SEQUENCES IN AN AGGRESSIVE HISTOLOGIC SUBTYPE OF ENDOMETRIAL CANCER

The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present, We have identified a region on the short arm o f chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32-33. Deletion of 1 p32-33 is seen more frequently in cancers of the highly aggressive pap illary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1 p32-33 which is specifically involved in the development of endometria l cancers with poor outcome.