SATURATION MULTIPOINT LINKAGE MAPPING OF CHROMOSOME 6Q IN TYPE-1 DIABETES

Linkage analysis of type 1 diabetes sib pair families (n = 334) has su ggested two separate regions of human chromosome 6q are linked to dise ase (designated IDDM5 and IDDM8), To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis, The two regions still showed positive evidence of linkage, most notably the pr oterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006 ; lambda(s) = 1.17). In addition, some evidence of transmission disequ ilibrium was seen with marker a046xa9 (IDDM5).