CYTOKINE INHIBITION PRESERVES RENAL HEMODYNAMIC FUNCTION FOLLOWING MESANGIAL CELL IMMUNE INJURY

Background: We assessed the effect of a cytokine inhibitor, compound S KF 86002 (a bicyclic imidazole), on changes in renal hemodynamics (ren al blood flow and glomerular filtration rate) that occur acutely follo wing immune injury of glomerular mesangial cells. Methods: injury was induced in Munich-Wistar rats by the administration of a monoclonal an tibody against the mesangial cell membrane antigen Thy 1.1. An acute d rop in renal blood flow (RPF) and glomerular filtration rate (GFR) occ urred within one hour of injury. Results: Pretreatment of animals with the cytokine inhibitor SKF 86002 prevented this drop, SKF 86002 had n o effect on glomerular synthesis of vasoconstrictor eicosanoids. Concl usions: The observations indicate that in mesangial cell immune injury , cytokines mediate renal hemodynamic impairment.