We elucidate the interplay between gauge and supersymmetry anomalies i
n six-dimensional N = 1 supergravity with generalized couplings betwee
n tensor and vector multiplets, We derive the structure of the five-di
mensional supergravity resulting from the Si reduction of these models
and give the constraints on Chem-Simons couplings that follow from du
ality to M-theory compactified on a Calabi-Yau threefold. The duality
is supported only on a restricted class of Calabi-Yau threefolds and r
equires a special type of intersection form. We derive five-dimensiona
l central-charge formulas and briefly discuss the associated phase tra
nsitions. Finally, we exhibit connections with F-theory compactificati
ons on Calabi-Yau manifolds that admit elliptic fibrations. This analy
sis suggests that F-theory unifies type-IIb three-branes and M-theory
five-branes.