The new phenols 6-oxo-tingenol, 3-O-methyl-6-oxo-tingenol and 6-oxo-ig
uesterol were isolated from the root bark of Maytenus canariensis. The
ir structures were determined by H-1 and C-13 NMR spectroscopic studie
s, including HMQC, HMBC, DEFT and ROESY and chemical transformations.
The synthesis of 6-oxo-tingenol was achieved from tingenone. These com
pounds exhibit antibiotic activity against Gram-positive bacteria. Cop
yright (C) 1996 Elsevier Science Ltd