NEOCLERODANE DITERPENOIDS FROM SCUTELLARIA-ORIENTALIS SUBSP PINNATIFIDA

Three new neo-clerodane derivatives, scutorientalins A-C, have been is olated from an acetone extract of the aerial parts of Scutellaria orie ntalis subsp. pinnatifida. The structures of the new diterpenoids, 19- acetoxy-6 alpha-isobutyroyloxy-4 alpha,18:8 beta,13S-diepoxy-neo-clero dan-15,16-olide, (scutorientalin A); (11S)-11-acetoxy-8 beta, 19-dihyd roxy-6 alpha-isobutyroyloxy-4 alpha, 18 epoxy-neo-cleroda-13-en-15,16- olide (scutorientalin B) and (11R)-11-hydroxy-19-acetoxy-6 alpha-isobu tyroyloxy-4 alpha,18:8 beta,13S-diepoxy-neo-clerodan-15,16-olide (scut orientalin C), were established by chemical and spectroscopic means an d by comparison with closely related compounds. Copyright (C) 1996 Els evier Science Ltd