COMPLETE SYNTHESIS OF 3'-SIALYL-N-ACETYLLACTOSAMINE BY REGIOSELECTIVETRANSGLYCOSYLATION

Authors
VETERE A PAOLETTI S
Citation
A. Vetere et S. Paoletti, COMPLETE SYNTHESIS OF 3'-SIALYL-N-ACETYLLACTOSAMINE BY REGIOSELECTIVETRANSGLYCOSYLATION, FEBS letters, 399(3), 1996, pp. 203-206
Citations number
29
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
399
Issue
3
Year of publication
1996
Pages
203 - 206
Database
ISI
SICI code
0014-5793(1996)399:3<203:CSO3BR>2.0.ZU;2-#
Abstract
Transglycolytic synthesis of 3'-sialyl-N-acetyllactosamine by sequenti al use of beta-galactosidase from Bacillus circulans and trans-sialida se from Trypanosoma cruzi was described. These reactions depicted the first complete synthesis of a biologically important oligosaccharide w ith high regioselectivity avoiding use of glycosyltransferases and NDP sugars.