Df. Fry et al., SYNTHESIS OF FUNCTIONALIZED CYCLIC IMINES BY ADDITION OF GRIGNARD-REAGENTS TO OMEGA-BROMONITRILES AND GAMMA,DELTA-UNSATURATED NITRILES, Tetrahedron letters, 37(35), 1996, pp. 6227-6230
Trimethylsilyloxy omega-bromonitriles and trimethylsilyloxy-gamma,delt
a-unsaturated nitriles give clean 1,2-addition products with Grignard
reagents that can be induced to undergo subsequent cyclization either
directly or by addition of N-bromosuccinimide, respectively. Copyright
(C) 1996 Elsevier Science Ltd