NUCLEOTIDE CARRIER MIXTURE WITH TRANSPORT SELECTIVITY FOR RIBONUCLEOSIDE-5'-PHOSPHATES

Authors
RIGGS JA HOSSLER KA SMITH BD KARPA MJ GRIFFIN G DUGGAN PJ
Citation
Ja. Riggs et al., NUCLEOTIDE CARRIER MIXTURE WITH TRANSPORT SELECTIVITY FOR RIBONUCLEOSIDE-5'-PHOSPHATES, Tetrahedron letters, 37(35), 1996, pp. 6303-6306
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
35
Year of publication
1996
Pages
6303 - 6306
Database
ISI
SICI code
0040-4039(1996)37:35<6303:NCMWTS>2.0.ZU;2-X
Abstract
A carrier mixture of lipophilic boronic acid and bis(quaternary ammoni um cation) greatly facilitates the transport of ribonucleoside monopho sphates through liquid organic membranes, at neutral pH. Transport sel ectivity was determined for the isomers of GMP. The observed order of noncompetitive transport rates war 5'-GMP > 2'-GMP > 3'-GMP. Copyright (C) 1996 Elsevier Science Ltd