PHOTO-TRIGGERED SELECTIVE C-TERMINAL N-METHYLAMIDATIVE CLEAVAGE OF POLYETHYLENEGLYCOL-BOUND PEPTIDES

Authors
AJAYAGHOSH A PILLAI VNR
Citation
A. Ajayaghosh et Vnr. Pillai, PHOTO-TRIGGERED SELECTIVE C-TERMINAL N-METHYLAMIDATIVE CLEAVAGE OF POLYETHYLENEGLYCOL-BOUND PEPTIDES, Tetrahedron letters, 37(35), 1996, pp. 6421-6424
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
35
Year of publication
1996
Pages
6421 - 6424
Database
ISI
SICI code
0040-4039(1996)37:35<6421:PSCNCO>2.0.ZU;2-7
Abstract
A navel liquid-phase method has been designed for the photolytic relea se of the attached peptides, directly as their C-terminal N-methylamid es, under mild conditions in excellent yields and purity. The present approach provides fully side-chain protected peptide N-methylamides, u seful for segment condensation and facilitate photo-controlled release of biologically active peptides for therapeutic applications. Copyrig ht (C) 1996 Published by Elsevier Science Ltd