CONTINUOUS LIQUID-LIQUID-EXTRACTION SPECTROPHOTOMETRIC DETERMINATION OF DIFLUNISAL

Authors
TRSKOVA R RYCHLOVSKY P NEMCOVA I TUREK P
Citation
R. Trskova et al., CONTINUOUS LIQUID-LIQUID-EXTRACTION SPECTROPHOTOMETRIC DETERMINATION OF DIFLUNISAL, Die Pharmazie, 51(8), 1996, pp. 550-553
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
51
Issue
8
Year of publication
1996
Pages
550 - 553
Database
ISI
SICI code
0031-7144(1996)51:8<550:CLSDO>2.0.ZU;2-Z
Abstract
A method has been proposed for the spectrophotometric determination of diflunisal (5-(2,4-difluorophenyl)salicyclic acid) using continuous f low analysis based on the formation of the methylene blue-diflunisal i on associate and its extraction into chloroform. The calibration curve was linear in the concentration range 1 . 10(-7) to 2 . 10(-5) mol . l(-1). The determination limit (10 sigma) was 1 . 10(-7) mol . l(-1). The sample analysis rate is 15 samples per hour.