PHARMACOKINETICS OF BETA-ESCIN AFTER ADMI NISTRATION OF DIFFERENT AESCULUS-EXTRACT CONTAINING FORMULATIONS

With a specific radioimmunoassay the pharmacokinetics and relative bio availability of escin was measured after administration of different f ormulations containing Aesculus-extract. Of special interest was the r elative bioavailability of escin after administration of a newly devel oped filmcoated tablet with sustained release in comparison to a refer ence formulation. In a cross-over steady-state study in 24 volunteers bioequivalence of test and reference preparation could be demonstrated . The 90% confidence interval of the AUC(0-tau) was 98,3 to 120,9%.