ANTIINFLAMMATORY AND ANALGESIC ACTIVITIES OF LONG-CHAIN PHENYL-SUBSTITUTED ALPHA-AMINO KETONES

The investigated phenyl substituted a-amino ketones have anti-inflamma tory and analgesic activities as could be shown in animal models (rats and mice). The effectiveness depends on the length of the alkyl chain . After i.p. application the most active amino ketones are ten times m ore effective than acetyl salicylic acid, but the activity did not rea ch that of indomethacine. The effective analgesic dose is ten times lo wer than that for anti-inflammatory action. Including the results of t he toxicity the analgesic efficiency of the amino ketones could be lea d to substances with high analgesic activity. After oral administratio n only in high doses anti-inflammatory and analgesic effectivities wer e found. The structural analog keto group instead of the ester or amid group leads not to the expected increase in p.o. effectivity.