PHARMACOKINETIC STUDIES OF THE FRAGRANCE COMPOUND 1,8-CINEOL IN HUMANS DURING INHALATION

Authors
JAGER W NASEL B NASEL C BINDER R STIMPFL T VYCUDILIK W BUCHBAUER G
Citation
W. Jager et al., PHARMACOKINETIC STUDIES OF THE FRAGRANCE COMPOUND 1,8-CINEOL IN HUMANS DURING INHALATION, Chemical senses, 21(4), 1996, pp. 477-480
Citations number
8
Categorie Soggetti
Physiology,Neurosciences,"Behavioral Sciences
Journal title
Chemical senses → ACNP
ISSN journal
0379864X
Volume
21
Issue
4
Year of publication
1996
Pages
477 - 480
Database
ISI
SICI code
0379-864X(1996)21:4<477:PSOTFC>2.0.ZU;2-M
Abstract
The present study was undertaken to investigate the pharmacokinetics o f 1,8-cineol in human subjects during prolonged inhalation. The result s showed that 1,8-cineol is well absorbed from breathing air, with a p eak plasma concentration after similar to 18 min. The elimination of t his fragrance compound from the blood is biphasic, with a mean distrib ution half-life of 6.7 min and an elimination half-life of 104.6 min.