LOW PERMEABILITIES OF APICAL MEMBRANES OF BARRIER EPITHELIA - WHAT MAKES WATERTIGHT MEMBRANES WATERTIGHT

Authors
Citation
Ml. Zeidel, LOW PERMEABILITIES OF APICAL MEMBRANES OF BARRIER EPITHELIA - WHAT MAKES WATERTIGHT MEMBRANES WATERTIGHT, American journal of physiology. Renal, fluid and electrolyte physiology, 40(2), 1996, pp. 243-245
Citations number
29
Categorie Soggetti
Physiology
ISSN journal
03636127
Volume
40
Issue
2
Year of publication
1996
Pages
243 - 245
Database
ISI
SICI code
0363-6127(1996)40:2<243:LPOAMO>2.0.ZU;2-C
Abstract
Several epithelia, including those of collecting duct (in the absence of antidiuretic hormone), thick ascending limb of Henle, and mammalian bladder exhibit extremely low permeabilities for water, small nonelec trolytes like urea, and protons. This brief review describes how apica l membrane structure might account for these low permeabilities by inc orporating recent biophysical and molecular modeling results.