Ml. Zeidel, LOW PERMEABILITIES OF APICAL MEMBRANES OF BARRIER EPITHELIA - WHAT MAKES WATERTIGHT MEMBRANES WATERTIGHT, American journal of physiology. Renal, fluid and electrolyte physiology, 40(2), 1996, pp. 243-245
Several epithelia, including those of collecting duct (in the absence
of antidiuretic hormone), thick ascending limb of Henle, and mammalian
bladder exhibit extremely low permeabilities for water, small nonelec
trolytes like urea, and protons. This brief review describes how apica
l membrane structure might account for these low permeabilities by inc
orporating recent biophysical and molecular modeling results.