TARGET DIRECTED ENEDIYNE PRODRUGS - HER AND AHR DEGRADATION BY A SYNTHETIC OXO-ENEDIYNE

Authors
JONES GB KILGORE MW POLLENZ RS LI AW MATHEWS JE WRIGHT JM HUBER RS TATE PL PRICE TL STICCA RP
Citation
Gb. Jones et al., TARGET DIRECTED ENEDIYNE PRODRUGS - HER AND AHR DEGRADATION BY A SYNTHETIC OXO-ENEDIYNE, Bioorganic & medicinal chemistry letters, 6(16), 1996, pp. 1971-1976
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
16
Year of publication
1996
Pages
1971 - 1976
Database
ISI
SICI code
0960-894X(1996)6:16<1971:TDEP-H>2.0.ZU;2-X
Abstract
An efficient route to oxo-enediynes is presented. A simple oxo-enediyn e has been synthesized, which cyclizes to give an isochroman. The agen t shows cytotoxicity for ER rich breast cancer cells and a model for i ts mode of action is proposed. Copyright (C) 1996 Elsevier Science Ltd .