P-NITROPHENYL 1,5-DITHIO-ALPHA-L-FUCOPYRANOSIDE - A NOVEL SULFUR BASED FUCOSIDASE INHIBITOR

Authors
TSURUTA O YUASA H HASHIMOTO H
Citation
O. Tsuruta et al., P-NITROPHENYL 1,5-DITHIO-ALPHA-L-FUCOPYRANOSIDE - A NOVEL SULFUR BASED FUCOSIDASE INHIBITOR, Bioorganic & medicinal chemistry letters, 6(16), 1996, pp. 1989-1992
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
16
Year of publication
1996
Pages
1989 - 1992
Database
ISI
SICI code
0960-894X(1996)6:16<1989:P1-ANS>2.0.ZU;2-S
Abstract
Five 5-thio-alpha-L-fucopyranosyl derivatives were prepared and examin ed as inhibitors of the alpha-L-fucosidase from bovine epididymis. The inhibitory activities of the fucosides strongly depend on the hydroph obicity of the aglycon. The best inhibition (K-i = 3.3 mu M) was obtai ned with p-nitrophenyl 1,5-dithio-alpha-L-fucopyranoside. Copyright (C ) 1996 Elsevier Science Ltd.