DIPHENYLMETHYL ETHERS - SYNTHESIS AND HISTAMINE H-3 RECEPTOR ANTAGONIST IN-VITRO AND IN-VIVO ACTIVITY

Authors
HULS A PURAND K STARK H LIGNEAU X ARRANG JM SCHWARTZ JC SCHUNACK W
Citation
A. Huls et al., DIPHENYLMETHYL ETHERS - SYNTHESIS AND HISTAMINE H-3 RECEPTOR ANTAGONIST IN-VITRO AND IN-VIVO ACTIVITY, Bioorganic & medicinal chemistry letters, 6(16), 1996, pp. 2013-2018
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
16
Year of publication
1996
Pages
2013 - 2018
Database
ISI
SICI code
0960-894X(1996)6:16<2013:DE-SAH>2.0.ZU;2-Q
Abstract
New potent histamine H-3-receptor antagonists containing an ether grou p were synthesized from 3-(1H-imidazole-4-yl)propanol and various subs tituted diphenylmethyl chlorides. Some of the designed ethers showed h igh activity at histamine H-3-receptors under in vitro as well as unde r in vivo conditions. Their activity at histamine H-1- and H-2-recepto rs was also investigated proving a pharmacological H-3-/H-1-antagonist ic profile. Copyright (C) 1996 Elsevier Science Ltd.