IMPROVED ANALOGS AND NOVEL DELIVERY SYSTEMS FOR SOMATOSTATIN OCTAPEPTIDES

Authors
MOREAU JP KIM S DONG JZ IGNATIOUS F JACKSON S MOREAU SC MORGAN BA TOURAUD F TAYLOR JE TISSIER B PELLET M MURPHY W DAVIS T
Citation
Jp. Moreau et al., IMPROVED ANALOGS AND NOVEL DELIVERY SYSTEMS FOR SOMATOSTATIN OCTAPEPTIDES, Metabolism, clinical and experimental, 45(8), 1996, pp. 24-26
Citations number
7
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Metabolism, clinical and experimental → ACNP
ISSN journal
00260495
Volume
45
Issue
8
Year of publication
1996
Supplement
1
Pages
24 - 26
Database
ISI
SICI code
0026-0495(1996)45:8<24:IAANDS>2.0.ZU;2-Q
Abstract
Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vi tro for the human SRIF receptor type 2 (hsst(2)). In addition, these m odifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both ph armacological and distribution studies in vivo with BIM-23190 and BIM- 23197 in the rat. Copyright (C) 1996 by W.B. Saunders Company