L. Cervo et al., 5-HT3 RECEPTOR ANTAGONISTS DO NOT MODIFY COCAINE PLACE CONDITIONING OR THE RISE IN EXTRACELLULAR DOPAMINE IN THE NUCLEUS-ACCUMBENS OF RATS, Pharmacology, biochemistry and behavior, 55(1), 1996, pp. 33-37
Three 5-HT3 receptor antagonists, MDL 72222, tropisetron, and ondanset
ron were studied for their ability to modify the conditioned place pre
ference (CPP) induced by 10 mg/kg IP cocaine in rats. MDL 72222 (0.03-
3 mg/kg SC) and tropisetron (0.01-0.1 mg/kg SC) administered, respecti
vely, 30 min and 1 h before each conditioning session, did not affect
the acquisition of cocaine CPP. Ondansetron (0.01-0.1 mg/kg SC) admini
stered 30 min before each conditioning session or just before testing
likewise had no effect. At 0.1 mg/kg SC ondansetron did not modify the
increase of extracellular dopamine caused by 10 mg/kg cocaine in the
nucleus accumbens. The results suggest that 5-HT3 receptor antagonists
have no effect on the rewarding properties of cocaine or on the behav
iour elicited by the stimuli previously associated with the drug's act
ion.