SURGERY AND POLYCHEMOTHERAPY OF NONFUNCTIONAL ENDOCRINE PANCREATIC TUMORS - A CASE-REPORT WITH A DRAMATIC CLINICAL-RESPONSE

Endocrine pancreatic tumors (EPT) are a rare clinical entity, represen ting 5% of all pancreatic tumors. Non-functional subtypes (NF-EPT) oft en present themselves at diagnosis in a locally advanced or metastatic stage. Therapeutic planning of these neoplasias is based on a multidi sciplinary integration of surgery and medical treatments. The Authors describe a case of NF-EPT with massive metastatic spread after cytored uctive surgery, with impressive response to polychemotherapy with 5-fl uorouracil, epirubicin and dacarbazine. The various options concerning chemotherapic treatment of these tumors are reviewed.