DETERMINATION OF HEMOGLOBIN A(1C) IN NORMAL AND DIABETIC MICE - NEONATAL STREPTOZOTOCIN-INDUCED DIABETIC MICE AND KK-AY MICE

Authors
KITAZAWA N MIURA T KAKO M USAMI M TANIGAWA K ISHIDA H SEINO Y
Citation
N. Kitazawa et al., DETERMINATION OF HEMOGLOBIN A(1C) IN NORMAL AND DIABETIC MICE - NEONATAL STREPTOZOTOCIN-INDUCED DIABETIC MICE AND KK-AY MICE, Biological & pharmaceutical bulletin, 19(8), 1996, pp. 1078-1079
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
19
Issue
8
Year of publication
1996
Pages
1078 - 1079
Database
ISI
SICI code
0918-6158(1996)19:8<1078:DOHAIN>2.0.ZU;2-R
Abstract
We have determined Hemoglobin A(1C) (HbA(1C)) in normal, neonatal stre ptozotocin-induced diabetic animals (NSZ), a model of lean-type non-in sulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia, and K K-AV mice, a model of obese-type NIDDM with hyperinsulinaemia. The HbA (1C) of NSZ mice was slight Ig increased from 5 to 20 weeks while the HbA(1C) of KK-Ay mice was markedly increased from 5 to 10 weeks, Our f indings showed a difference between experiment ally-induced (NSZ) and genetically (KK-Ay) diabetic animals.