TAKING AIM AT A MOVING TARGET - INHIBITORS OF INFLUENZA-VIRUS .2. VIRAL REPLICATION, PACKAGING AND RELEASE

in this two part review, the current status of influenza research is s ummarized in the context of inhibitor design and discovery. in Part 1, published in the August edition of Drug Discovery Today, the authors considered therapeutic approaches to influenza through interference wi th early phases of the virus life cycle. in Part 2, the authors descri be the current level of understanding of the biochemical aspects of vi ral replication, packaging and release, and recent progress in the des ign and identification of potent and selective inhibitors of these cru cial stages in the life cycle. Recent developments at both the preclin ical and the clinical level highlight the considerable potential of th is area of influenza inhibitor drug discovery.