V. Perez et al., KINETIC-STUDIES OF N-ALLENIC ANALOGS OF TRYPTAMINE AS MONOAMINE-OXIDASE INHIBITORS, Journal of Pharmacy and Pharmacology, 48(7), 1996, pp. 718-722
A series of N-allenic analogues of tryptamine in which the side chain
is located at the 2 position of the indole ring, but which differed in
the ring and side-chain nitrogen substituents, were assayed kinetical
ly as MAO A and MAO B inhibitors. All the compounds studied were mecha
nism-based inhibitors. The kinetic constants of each inhibition step K
-i and k(i), were determined for both MAO A and B. The data obtained i
ndicated that these allenic derivatives show a greater selectivity and
potency towards MAO A as inhibitors than the corresponding acetylenic
derivatives.