Therapeutic approaches to anaerobic infections are changing. Debrideme
nt, drainage, and other surgical approaches remain extremely important
. Resistance to antimicrobial agents currently used for treatment of a
naerobic infections is increasing. However, promising new agents are b
eing introduced. We review the current status of therapy for anaerobic
infections and discuss the potential role of these new agents. We str
ess an empirical approach to therapy that is based on the usual infect
ing flora in various types of infections.