STUDIES ON THE SYNTHESIS OF CHOLECYSTOKIN IN A RECEPTOR ANTAGONISTS .3. SYNTHESIS AND CHOLECYSTOKININ A RECEPTOR INHIBITORY ACTIVITIES OF NAPHTHYL SULFONE DERIVATIVES

Authors
AJISAWA Y KITAZAWA M NAKANO Y TSUBAKI A BAN M SATO K OKAZAKI K UCHIDA M KOBAYASHI M
Citation
Y. Ajisawa et al., STUDIES ON THE SYNTHESIS OF CHOLECYSTOKIN IN A RECEPTOR ANTAGONISTS .3. SYNTHESIS AND CHOLECYSTOKININ A RECEPTOR INHIBITORY ACTIVITIES OF NAPHTHYL SULFONE DERIVATIVES, Yakugaku zasshi, 116(8), 1996, pp. 647-656
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Yakugaku zasshi → ACNP
ISSN journal
00316903
Volume
116
Issue
8
Year of publication
1996
Pages
647 - 656
Database
ISI
SICI code
0031-6903(1996)116:8<647:SOTSOC>2.0.ZU;2-O
Abstract
A number of naphthyl sulfone derivatives were synthesized and tested f or cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inh ibitory activities were found in sulfone-carboxylic acid derivatives ( 7) having very hydrophobic sidechains. As the most preferred compound, N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid ((R)-7c) was selected.