ANGIOTENSIN I-CONVERTING ENZYME-INHIBITORS IN AUTOLYSATES OF SQUID LIVER AND MANTLE MUSCLE

Authors
WAKO Y ISHIKAWA S MURAMOTO K
Citation
Y. Wako et al., ANGIOTENSIN I-CONVERTING ENZYME-INHIBITORS IN AUTOLYSATES OF SQUID LIVER AND MANTLE MUSCLE, Bioscience, biotechnology, and biochemistry, 60(8), 1996, pp. 1353-1355
Citations number
13
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
60
Issue
8
Year of publication
1996
Pages
1353 - 1355
Database
ISI
SICI code
0916-8451(1996)60:8<1353:AIEIAO>2.0.ZU;2-0
Abstract
Autolysis of squid liver and mantle muscle homogenates, and blends of both, each yielded inhibitory activity toward the angiotensin I-conver ting enzyme. The inhibitory activity and the amount of solubilized pro tein in each of these autolysates were examined over a period of 24 h. Inhibitory peptides were isolated from the mixed autolysate, their st ructures (IC50) being Tyr-Ala-Leu-Pro-His-Ala (9.8 mu M) and Gly-Tyr-A la-Leu-Pro-His-Ala (27.3 mu M).