INTEGRATED SENSOR-TELEMETRY SYSTEM FOR IN-VIVO GLUCOSE MONITORING

This paper reports the development of an electronics package designed for use with an implantable amperometric glucose biosensor. The packag e includes a potentiostat to bias the sensor and a telemetry unit to t ransmit information from the sensor to an external receiver and data-c ollection computer. The device components and package have been evalua ted in vitro. Initial tests are performed with non-encapsulated electr onics and the sensor partly submerged in a glucose solution. To simula te the implantation conditions, tests have been conducted with the ele ctronics encapsulated in plastic (epoxy resin or silicone elastomer ma trix) and submerged in a 37 degrees C water bath. These tests verify t hat the telemetry system is transmitting through an aqueous solution w ith a water mass equivalent to a medium sized dog. Calibration curves of the received signal versus glucose concentration in model solutions have been obtained. The correlation between data obtained using a tra ditional potentiostat and the data obtained via telemetry allows the c ommencement of in vivo experimentation.