NEW HYDROLYZABLE TANNINS, SHEPHAGENIN-A AND SHEPHAGENIN-B, FROM SHEPHERDIA-ARGENTEA AS HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS

Authors
YOSHIDA T ITO H HATANO T KURATA M NAKANISHI T INADA A MURATA H INATOMI Y MATSUURA N ONO K NAKANE H NODA M LANG FA MURATA J
Citation
T. Yoshida et al., NEW HYDROLYZABLE TANNINS, SHEPHAGENIN-A AND SHEPHAGENIN-B, FROM SHEPHERDIA-ARGENTEA AS HIV-1 REVERSE-TRANSCRIPTASE INHIBITORS, Chemical and Pharmaceutical Bulletin, 44(8), 1996, pp. 1436-1439
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
8
Year of publication
1996
Pages
1436 - 1439
Database
ISI
SICI code
0009-2363(1996)44:8<1436:NHTSAS>2.0.ZU;2-A
Abstract
Two new hydrolyzable tannins, shephagenins A and B, were isolated alon g with hippophaenin A and strictinin from the leaf extract of Shepherd ia augentea, which showed a remarkable inhibitory activity against hum an immunodeficiency virus (HIV)-1 reverse transcriptase. Their structu res, having a gluconic acid core, have been elucidated on the basis of spectroscopic and chemical methods. The inhibitory effect of the leaf extract on HIV-1 reverse transcriptase was found to be due to tannins , and their activities were stronger than that of (-)-epigallocatechin gallate as a positive control.