SYNTHESIS AND TRYPTIC HYDROLYSIS OF P-GUANIDINOPHENYL ESTERS DERIVED FROM AMINO-ACIDS AND PEPTIDES

Authors
SEKIZAKI H ITOH K TOYOTA E TANIZAWA K
Citation
H. Sekizaki et al., SYNTHESIS AND TRYPTIC HYDROLYSIS OF P-GUANIDINOPHENYL ESTERS DERIVED FROM AMINO-ACIDS AND PEPTIDES, Chemical and Pharmaceutical Bulletin, 44(8), 1996, pp. 1577-1579
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
8
Year of publication
1996
Pages
1577 - 1579
Database
ISI
SICI code
0009-2363(1996)44:8<1577:SATHOP>2.0.ZU;2-3
Abstract
A facile synthetic method for p-guanidinophenyl esters derived from a variety of amino acids and peptides, including D-amino acids, is prese nted, The kinetic behavior of trypsin towards these synthetic esters, inverse substrates, was analyzed, The spatial requirement of the enzym e active site for catalytic efficiency is discussed based on the steri c characteristics of the substrates.