HIGH-INCIDENCE OF TRIPLOIDY IN IN-VITRO FERTILIZED OOCYTES FROM A PATIENT WITH A PREVIOUS HISTORY OF RECURRENT GESTATIONAL TROPHOBLASTIC DISEASE

The patient described has a history of recurrent gestational trophobla stic disease following spontaneous conception, She subsequently underw ent two cycles of in-vitro fertilization (IVF) for management of infer tility related to tubal obstruction, IVF of the oocytes retrieved show ed a significantly high incidence of abnormal fertilization resulting in the development of triploid embryos. This report explores the possi ble association of an oocyte defect predisposing to abnormal fertiliza tion, resulting in a high incidence of triploid embryos, Since the dev elopment of partial hydatidiform moles is related to the origin of tri ploidy, this phenomenon is suggested to explain the occurrence of recu rrent trophoblastic disease in this patient. We propose the use of int racytoplasmic sperm injection (ICSI) as a therapeutic option to minimi ze the incidence of triploidy in future IVF cycles; donor oocyte IVF w ould be another alternative.