PERINATAL OUTCOME AND FOLLOW-UP OF 82 CHILDREN AGED 1-9 YEARS OLD CONCEIVED FROM CRYOPRESERVED EMBRYOS

Embryo cryopreservation is routinely used in in-vitro fertilization (I VF)-embryo transfer programmes, Yet very few studies have reported the follow-up of children conceived with frozen/thawed embryos, This stud y was designed to follow up the total cohort of children conceived wit h cryopreserved :embryos in A, Beclere Hospital in Clamart, France bet ween 1986 and 1994, We were able to study 89 children, aged 1-9 years old, out of the 93 conceived during this period (lost to follow-up: 4. 3%), The prematurity rate was 14.7% for the singleton and 85.7% for th e twins. Half of these premature deliveries occurred during the 36th w eek of amenorrhea, In all, 8% of the singleton and 28.6% of the twins were small for gestational age, At the time of the study, only three c hildren aged 1 and 2 years old were below the 10th percentile, The tot al malformation rate was 3.4% when two abortions performed during the study period were added to the one (short ureter) found in our study g roup, The medical and surgical illness as well as principal acquisitio ns for children <5 years old and scholastic performance for older chil dren did not show pathological features.